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Dr. D. Isaac Gaines

Dr. D. Isaac Gaines


Areas of Care:

  • Gastroenterology


  • Colonoscopy
  • Upper Endoscopy
  • Gastroesophageal Reflux Disease (GERD)
  • Irritable Bowel Syndrome (IBS)
  • Celiac Disease
  • Ulcerative Colitis
  • Abdominal Pain

Dr. D. Isaac Gaines has more than a decade in medical training and experience. He received his undergraduate degree in biology from Birmingham-Southern College in Alabama. He continued with his education and graduated from the University of Alabama-School of Medicine, where he also completed his internship and residency. He was chosen to be the chief resident and instructor before deciding to pursue a fellowship at the Medical University of South Carolina for gastroenterology and hepatology.

He chose his fellowship because he felt he connected with patients with liver disease while he was a medical student. He enjoyed the relationships he developed with people with life-threatening illnesses and the complexity of liver disease.

Dr. Gaines is presently a member of the Greenville County Medical Society, South Carolina Medical Association, South Carolina Gastroenterology Association, and American College of Gastroenterology. He is board certified with the American Board of Internal Medicine for Gastroenterology.

Dr. Gaines is originally from Alabama but enjoys the Greenville area for the outdoor opportunities. "I can be hiking in the mountains, riding my bike, or kayaking on a lake, all within an hour's drive."

Patient Satisfaction

Dr. Gaines’s ratings are among the best for Greenville Gastroenterologists, receiving a rating of over four stars on Healthgrades. Among his highest ratings are his trustworthiness, ability to answer questions and time spent with patient. One five-star reviewer says:

“Very kind and patient with me before, during and after my procedure. Took time to explain things to me thoroughly. Very satisfied and would recommend him to others.”


  • 1996, B.S. Biology, History Minor
    Birmingham-Southern College, Birmingham, AL

Medical School

  • 2000, MD Degree
    University of Alabama School of Medicine


  • July 2000-June 2001 (Internal Medicine)
    University of Alabama at Birmingham, Birmingham, AL


  • July 2001-May 2003 (Internal Medicine)
    University of Alabama at Birmingham, Birmingham, AL 
  • June 2003-June 2004, Chief Resident/Instructor in Medicine
    University of Alabama at Birmingham, Birmingham, AL


  • July 2004-July 2007 (Gastroenterology/Hepatology)
    Medical University of South Carolina, Charleston, SC

Board Certification

  • American Board of Internal Medicine, Gastroenterology

Affiliations & Associations

  • Greenville County Medical Society
  • South Carolina Medical Association
  • South Carolina Gastroenterology Association


To Schedule Your GI Procedure with Dr. Gaines, Please Complete the Form Below or Call (864) 232-7338

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