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Dr. Greg S. Holt

Dr. Greg S. Holt


Areas of Care:

  • Gastroenterology
  • Internal Medicine


  • Colonoscopy
  • Upper Endoscopy
  • Gastroesophageal Reflux Disease (GERD)
  • Irritable Bowel Syndrome (IBS)
  • Celiac Disease
  • Ulcerative Colitis
  • Abdominal Pain

Dr. Greg S. Holt has more than three decades of medical training and experience. He first started his college career by attending Valparaiso University, where he graduated with his B.S. in Chemistry and Biology. He then proceeded on to the University of Illinois to complete his M.D. degree. He finished up his internship, residency, and fellowship in gastroenterology all at Bowman Gray School of Medicine in North Carolina.

Dr. Holt is board certified in both internal medicine and gastroenterology. He is a member of the American College of Gastroenterology, Greenville County Medical Society, South Carolina Gastroenterology Association, South Carolina Medical Association, and the American Medical Association.

Patient Satisfaction

Dr. Holt’s ratings are among the best for Greenville Gastroenterologists, receiving a combined average rating of more than 3.5 stars on Healthgrades, Vitals and Google My Business. Among his highest ratings are his trustworthiness, ability to answer questions and time spent with patient. One five-star reviewer says:

“I had experienced a chronic condition that required multiple surgeries and treatments. Doctors had given up on finding the root cause. Dr. Holt listened to my story, looked at my records and predicted that he knew how to fix the problem. For confirmation, he ordered a couple tests and he confirmed his diagnosis. One more minor surgery and my almost 5 years of various treatments were over. I will be forever grateful to Dr. Holt for restoring a quality life for me.”


  • 1984, B.S. Biology and Chemistry
    Valparaiso University, Valparaiso, IL

Medical School

  • 1987, MD Degree
    University of Illinois, Peoria, IL


  • July 1987-July 1988 (Internal Medicine)
    Bowman Gray School of Medicine, Winston Salem, NC


  • July 1988-July 1990 (Internal Medicine)
    Bowman Gray School of Medicine, Winston Salem, NC


  • July 1991-July 1993 (Gastroenterology)
    Bowman Gray School of Medicine, Winston Salem, NC

Board Certification

  • American Board of Internal Medicine, Internal Medicine 
  • American Board of Internal Medicine, Gastroenterology

Affiliations and Associations

  • American College of Gastroenterology
  • South Carolina Gastroenterology Association
  • American Medical Association
  • Greenville County Medical Society (GCMS)
  • South Carolina Medical Association (SCMA)


To Schedule Your GI Procedure with Dr. Holt, Please Complete the Form Below or Call (864) 232-7338

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